反应详情

A mixture of 4-amino-5-chloro-N-[(4-ethoxycarbonyl-2-morpholinyl)methyl]-2-methoxybenzamide (6.1 g), potassium hydroxide (10.1 g), and isopropyl alcohol (60 ml) is refluxed with stirring for 3 hours. The reaction mixture is concentrated under reduced pressure, and the residue is diluted with water and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure, and the residue is recrystallized from isopropyl alcohol to give the title compound (1.4 g), mp 161°-162° C.

1. temperatureis refluxed
2. concentrationThe reaction mixture is concentrated under reduced pressure
3. additionthe residue is diluted with water
4. extractionextracted with chloroform
5. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
6. dry with materialdried over magnesium sulfate
7. distillationThe solvent is distilled off under reduced pressure
8. customthe residue is recrystallized from isopropyl alcohol