n-((4-Benzylmorpholin-2-yl)methyl)acetamide → N-(morpholin-2-ylmethyl)acetamide

Participants

Reaction Steps

2-Acetylaminomethyl-4-benzylmorpholine (120 g) is dissolved in a mixture of ethanol (1000 ml) and acetic acid (30 ml) and hydrogenated over 10% palladium on carbon (5 g) at about 60° C. After the calculated amount of the hydrogen is absorbed, the catalyst is filtered off. The filtrate is evaporated under reduced pressure to give the title compound as an oil.

Provenance & Evidence