反应详情

A solution of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine (3.0 g) in 10% hydrochloric acid (50 ml) is refluxed with stirring for 4 hours. The reaction mixture is adjusted to pH 11 with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound as an oil.

1. extractionextracted with chloroform
2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. customRemoval of the solvent under reduced pressure