HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1608215Generated: November 2, 2026
Dimethyl Sulfoxide → 4-Benzyl-2-morpholineacetonitrile
https://huagongshe.com/reaction/1608215
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 4-Benzyl-2-(chloromethyl)morpholine | HCID 2801562 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Benzyl-2-morpholineacetonitrile | HCID 3248416 | 92.8% |
Reaction Steps
A mixture of 4-benzyl-2-chloromethylmorpholine (22.5 g), potassium cyanide (13 g), potassium iodide (1 g), and dimethyl sulfoxide (40 ml) is heated with stirring at 120° C. for 5 hours. The reaction mixture is cooled, diluted with water, and extracted with diethyl ether. The organic layer is washed with water, dried over sodium sulfate, and evaporated to give the title compound (20 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04870074 |
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| Source dataset | uspto-grants-1989_09 |
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| ORD ID | ord-41e789ef8c1144c2a2c531ef8c2002fc |
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| Source note | uspto-grants-1989_09 |
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