反应详情

温度

120 °C

A mixture of 4-benzyl-2-chloromethylmorpholine (22.5 g), potassium cyanide (13 g), potassium iodide (1 g), and dimethyl sulfoxide (40 ml) is heated with stirring at 120° C. for 5 hours. The reaction mixture is cooled, diluted with water, and extracted with diethyl ether. The organic layer is washed with water, dried over sodium sulfate, and evaporated to give the title compound (20 g) as an oil.

1. temperatureis heated
2. temperatureThe reaction mixture is cooled
3. extractionextracted with diethyl ether
4. washThe organic layer is washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated