Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-Benzylmorpholin-2-yl)ethan-1-ol | HCID 14652591 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 19848591 | HCID 19848591 | — |
Reaction Steps
To a mixture of 2-(2-hydroxyethyl)-4-benzylmorpholine (27.7 g), triethylamine (28 ml), and ethyl acetate (100 ml) is dropwise added acetic anhydride (17.8 ml). The reaction mixture is stirred at 25° C. for 1 hour and evaporated under reduced pressure. The residue is dissolved in chloroform and chromatographed on silica gel. Fractions containing the title compound are pooled and evaporated to give the title compound (29.1 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04870074 |
|---|
| Source dataset | uspto-grants-1989_09 |
|---|
| ORD ID | ord-b3b31a3f49f8428eafef6c5ad638ed59 |
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| Source note | uspto-grants-1989_09 |
|---|
