Acetic Anhydride → HCID 19848591, compound

HRID 1608217Notes

Reaction equation

HRID 1608217 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5]1.C(N(CC)CC)C.[C:24](OC(=O)C)(=[O:26])[CH3:25]>C(OCC)(=O)C>[C:24]([O:1][CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5]1)(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 146525912-(4-Benzylmorpholin-2-yl)ethan-1-ol

Product 1

HCID 19848591HCID 19848591, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
25 °C

Procedure

To a mixture of 2-(2-hydroxyethyl)-4-benzylmorpholine (27.7 g), triethylamine (28 ml), and ethyl acetate (100 ml) is dropwise added acetic anhydride (17.8 ml). The reaction mixture is stirred at 25° C. for 1 hour and evaporated under reduced pressure. The residue is dissolved in chloroform and chromatographed on silica gel. Fractions containing the title compound are pooled and evaporated to give the title compound (29.1 g) as an oil.

Workup

  1. customevaporated under reduced pressure
  2. dissolutionThe residue is dissolved in chloroform
  3. customchromatographed on silica gel
  4. additionFractions containing the title compound
  5. customevaporated

Sources & evidence

ORD record
ord-b3b31a3f49f8428eafef6c5ad638ed59
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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