Dimethylformamide → HCID 14882033, compound

HRID 1608220Notes

Reaction equation

HRID 1608220 reaction equation
O[CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:5]1.CN(C)C=O.S(Cl)([Cl:27])=O>C(Cl)(Cl)Cl>[Cl:27][CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:5]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 19848597HCID 19848597, compound

Product 1

HCID 14882033HCID 14882033, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a mixture of 2-(2-hydroxyethyl)-4-benzyloxycarbonylmorpholine (15 g), dimethylformamide (1 ml), and chloroform (50 ml) is dropwise added thionyl chloride (16.3 ml). The mixture is refluxed for 2 hours, allowed to cool, and evaporated under reduced pressure to give the title compound (16 g) as an oil.

Workup

  1. temperatureThe mixture is refluxed for 2 hours
  2. temperatureto cool
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-ee312d2b52904a84b5270e369b93fb68
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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