HCID 14882034, compound → HCID 19848620, compound

HRID 1608222Notes

Reaction equation

HRID 1608222 reaction equation
[C:1]([CH2:3][CH2:4][CH:5]1[O:10][CH2:9][CH2:8][N:7](C(OCC2C=CC=CC=2)=O)[CH2:6]1)#[N:2]>C(O)C.[Pd]>[C:1]([CH2:3][CH2:4][CH:5]1[O:10][CH2:9][CH2:8][NH:7][CH2:6]1)#[N:2]

Participants

4

Reactant 1

HCID 14882034HCID 14882034, compound

Product 1

HCID 19848620HCID 19848620, compoundYield 98.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-(2-cyanoethyl)-4-benzyloxycarbonylmorpholine (10.7 g) in ethanol (60 ml) is hydrogenated over 5% palladium on carbon (1 g) at 25° C. After the calculated amount of hydrogen is absorbed, the catalyst is filtered off. The filtrate is evaporated under reduced pressure to give the title compound (5.4 g) as an oil.

Workup

  1. customAfter the calculated amount of hydrogen is absorbed
  2. filtrationthe catalyst is filtered off
  3. customThe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-a1e2b18fd18e45feb9bf85c08b75f2de
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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