HCID 19848614, compound → HCID 14881837, compound

HRID 1608224Notes

Reaction equation

HRID 1608224 reaction equation
[C:1]([CH2:3][CH2:4][CH:5]1[O:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1)#[N:2]>C(O)C.O.N.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][CH:5]1[O:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1

Participants

5

Reactant 1

HCID 19848614HCID 19848614, compound

Product 1

HCID 14881837HCID 14881837, compoundYield 86%

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 12896473Azane;hydrateSolvent

Procedure

A solution of 2-(2-cyanoethyl)-4-benzylmorpholine (8 g) in a mixture of ethanol (60 ml) and 28% ammonia water (4 ml) is hydrogenated over Raney nickel at 25° C. After the calculated amount of hydrogen is absorbed, the catalyst is filtered off. The filtrate is evaporated under reduced pressure to give the title compound (7 g) as an oil.

Workup

  1. customAfter the calculated amount of hydrogen is absorbed
  2. filtrationthe catalyst is filtered off
  3. customThe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-6913707d6d5a4a51b311a2425cfcfefa
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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