反应详情

温度

150 °C

A mixture of 4-(2-chlorobenzyl)-2-chloromethyl-6-methylmorpholine (19.7 g), phthalimide potassium salt (14.6 g), and dimethylformamide (150 ml) is stirred at 150° C. for 5 hours. The reaction mixture is poured into ice-water and extracted with diethyl ether. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off to give the title compound (26 g) as an oil.

1. extractionextracted with diethyl ether
2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. distillationThe solvent is distilled off