Sodium Hydroxide → HCID 10037975, compound

HRID 1608228Notes

Reaction equation

HRID 1608228 reaction equation
C([NH:4][CH2:5][CH:6]1[O:11][CH:10]([CH3:12])[CH2:9][N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[CH2:7]1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][CH2:5][CH:6]1[O:11][CH:10]([CH3:12])[CH2:9][N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[CH2:7]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 198486042-Acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine

Product 1

HCID 10037975HCID 10037975, compoundYield 85.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2-acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine (3.0 g) in 10% hydrochloric acid (60 ml) is refluxed with stirring for 2 hours. The reaction mixture is basified with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium choride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give the title compound (2.2 g) as an oil.

Workup

  1. extractionextracted with chloroform
  2. washThe organic layer is washed successively with water and saturated aqueous sodium choride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent is distilled off under reduced pressure

Sources & evidence

ORD record
ord-d831fa94c3bb4e4887f42133d93c4b5a
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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