反应详情

A solution of 2-acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine (3.0 g) in 10% hydrochloric acid (60 ml) is refluxed with stirring for 2 hours. The reaction mixture is basified with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium choride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give the title compound (2.2 g) as an oil.

1. extractionextracted with chloroform
2. washThe organic layer is washed successively with water and saturated aqueous sodium choride solution
3. dry with materialdried over magnesium sulfate
4. distillationThe solvent is distilled off under reduced pressure