Methylamine → HCID 19848623, compound

HRID 1608237Notes

Reaction equation

HRID 1608237 reaction equation
[CH3:1][N:2]([CH3:16])[S:3]([C:6]1[CH:7]=[CH:8][C:9](F)=[C:10]([CH:14]=1)[C:11]([OH:13])=[O:12])(=[O:5])=[O:4].[CH3:17][NH2:18]>>[CH3:17][NH:18][C:9]1[CH:8]=[CH:7][C:6]([S:3](=[O:5])(=[O:4])[N:2]([CH3:16])[CH3:1])=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 24926795-(N,N-diMethylsulfaMoyl)-2-fluorobenzoic acid

Product 1

HCID 19848623HCID 19848623, compound

Procedure

A mixture of 5-dimethylsulfamoyl-2-fluorobenzoic acid (10 g) and 40% aqueous methylamine solution (85 ml) is refluxed for 24 hours and then evaporated under reduced pressure. The residue is adjusted to the pH of about 4 with acetic acid. The precipitate is collected, washed with water, and dried to give the title compound (6.0 g).

Workup

  1. temperatureis refluxed for 24 hours
  2. customevaporated under reduced pressure
  3. customThe precipitate is collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-162e0f9f382343668007b927b9ca70ad
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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