Hydrochloric Acid → HCID 19849120, compound

HRID 1608320Notes

Reaction equation

HRID 1608320 reaction equation
[OH-].[Na+].C([O:5][C:6]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH:16]=[N:15]2)=[O:7])C.Cl>C(O)C>[C:6]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH:16]=[N:15]2)([OH:7])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19849123HCID 19849123, compound

Product 1

HCID 19849120HCID 19849120, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2N-NaOH 6 ml was added to compound 914 (1 g, 3.6 mM, as the starting material) dissolved in 50% aqueous ethanol 50 ml and the mixture was stirred at room temperature for 1-1.5 hour. Dilute HCl was added to the reaction mixture to adjust it to an acidic pH, and the solvent was distilled off in vacuo. The residue was dried in vacuo to obtain crude 6-(3-carboxypropoxy)-2-oxo-1,2-dihydroquinoxaline (compound 938).

Workup

  1. distillationthe solvent was distilled off in vacuo
  2. customThe residue was dried in vacuo

Sources & evidence

ORD record
ord-21bc2e3fc7314043aaae116f1f31d50b
Source dataset
uspto-grants-1989_09
Patent number
US04870175

Reaction notes

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