Hydrochloric Acid → HCID 19849132, compound

HRID 1608323Notes

Reaction equation

HRID 1608323 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[C:5](=[O:24])[NH:6][C:7]2[C:12]([N:13]=1)=[CH:11][C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])=[CH:9][CH:8]=2.O.Cl>CO>[CH3:3][C:4]1[C:5](=[O:24])[NH:6][C:7]2[C:12]([N:13]=1)=[CH:11][C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:9][CH:8]=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 53717315HCID 53717315, compound

Product 1

HCID 19849132HCID 19849132, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2N-NaOH solution 29.6 ml was added to the compound 1036 (8.99 g, 29.6 mM) suspended in methanol 29.6 ml and the mixture was stirred overnight. Water 88.8 ml was added to the reaction mixture, and the mixture was adjusted to pH 2 by adding 6N-HCl. Precipitated crystals were collected by filtration, washed completely with water and dried to obtain the compound 1037.

Workup

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed completely with water
  4. customdried

Sources & evidence

ORD record
ord-c9b1ffab7734460c85beaf40fb6d2548
Source dataset
uspto-grants-1989_09
Patent number
US04870175

Reaction notes

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