Hydrochloric Acid → HCID 19849129, compound

HRID 1608324Notes

Reaction equation

HRID 1608324 reaction equation
[OH-:1].[Na+].[CH2:3]([CH:5]1[N:14](OCCCCC(OCC)=O)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:25])[CH3:4].[OH2:26].Cl.[CH3:28][OH:29]>>[CH2:3]([C:5]1[C:6](=[O:25])[NH:7][C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([O:1][CH2:4][CH2:3][CH2:5][CH2:6][C:28]([OH:29])=[O:26])=[CH:10][CH:9]=2)[CH3:4]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 54549139HCID 54549139, compound

Product 1

HCID 19849129HCID 19849129, compound

Procedure

2N-NaOH solution 28.0 ml was added to the compound 1012 (8.90 g, 28.9 mM) suspended in methanol 28.0 ml and the mixture was stirred overnight. Water 84.0 ml was added to the reaction mixture, and the mixture was adjusted to pH 2 by adding 6N-HCl. Precipitated crystals were collected by filtration, washed completely with water and dried to obtain the compound 1013.

Workup

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed completely with water
  4. customdried

Sources & evidence

ORD record
ord-041ed303da7a4bcdb941f7885d8cca68
Source dataset
uspto-grants-1989_09
Patent number
US04870175

Reaction notes

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