Potassium Carbonate → Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

HRID 1608354노트

반응식

HRID 1608354 반응식
Cl[C:2]1[C:24]([N+:25]([O-:27])=[O:26])=[C:23]([Cl:28])[C:22]([F:29])=[CH:21][C:3]=1[C:4]([C:6](=[CH:12][NH:13]CCC(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:28][C:23]1[C:24]([N+:25]([O-:27])=[O:26])=[C:2]2[C:3]([C:4]([OH:5])=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:12]=[N:13]2)=[CH:21][C:22]=1[F:29]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 178472018HCID 178472018, 화합물

생성물 1

HCID 178469671Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

52 g of the product from Example 4 and 18.5 g of K2CO3 are heated at 140° C. for 4 hours in 160 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is isolated. It is dried and recrystallized from glycol methyl ether acetate. Yield: 35.8 g, melting point: 226°-8° C. (decomposes).

후처리

  1. additionThe mixture is subsequently poured onto ice
  2. customthe precipitated solid is isolated
  3. customIt is dried
  4. customrecrystallized from glycol methyl ether acetate

출처 및 근거

ORD 기록
ord-99651179dc094d97bd800861366c4e9b
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870182

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