Potassium Carbonate → Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

Participants

Reaction Steps

52 g of the product from Example 4 and 18.5 g of K2CO3 are heated at 140° C. for 4 hours in 160 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is isolated. It is dried and recrystallized from glycol methyl ether acetate. Yield: 35.8 g, melting point: 226°-8° C. (decomposes).

Provenance & Evidence