HCID 178472080, compound → Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

HRID 1608358Notes

Reaction equation

HRID 1608358 reaction equation
[NH2:1][CH:2]=[C:3]([C:9](=[O:22])[C:10]1[CH:15]=[C:14]([F:16])[C:13]([Cl:17])=[C:12]([N+:18]([O-:20])=[O:19])[C:11]=1Cl)[C:4]([O:6][CH2:7][CH3:8])=[O:5]>O1CCOCC1>[Cl:17][C:13]1[C:12]([N+:18]([O-:20])=[O:19])=[C:11]2[C:10]([C:9]([OH:22])=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH:2]=[N:1]2)=[CH:15][C:14]=1[F:16]

Participants

3

Reactant 1

HCID 178472080HCID 178472080, compound

Product 1

HCID 178469671Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

7.0 g of the product from Example 8 are initially introduced into 100 ml of dioxane. 4.7 g of potassium tert.-butylate are added to this in portions. The mixture is stirred for 24 hours at room temperature, poured onto ice, and neutralized. The precipitated solid is isolated and dried. Yield: 5.3 g, melting point: 224°-7° (decomposes)

Workup

  1. additionpoured onto ice
  2. customThe precipitated solid is isolated
  3. customdried

Sources & evidence

ORD record
ord-6a27ac59c602434099df9c2ef2456602
Source dataset
uspto-grants-1989_09
Patent number
US04870182

Reaction notes

Loading…