HCID 53685369, compound → HCID 54375809, compound

HRID 1608403Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)=[C:9]([N:23]2[C:27]([C:28]3C=CC=CC=3)=[N:26][N:25]=[N:24]2)[CH:10]=[CH:11][CH:12]([OH:22])[CH2:13][C:14](=[O:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:4][CH:3]=1.FC1C=CC(C(C2C=CC(F)=CC=2)=C(N2C(C)=NN=N2)C=CC(O)CC(=O)CC([O-])=O)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)=[C:9]([N:23]2[C:27]([CH3:28])=[N:26][N:25]=[N:24]2)[CH:10]=[CH:11][CH:12]([OH:22])[CH2:13][CH:14]([OH:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 53685369HCID 53685369, compound

HCID 73668863HCID 73668863, compound

Product 1

HCID 54375809HCID 54375809, compoundYield 63%

Procedure

The general procedure of Example 9 was repeated except that the ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(5-phenyl-1H-tetrazol-1-yl)-3-oxo-6,8-nonadienoate utilized therein was replaced by 2.0 g of 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(5-methyl-1H-tetrazol-1-yl)-3-oxo-6,8-nonadienoate and there was thereby produced 1.25 g (63%) of the title compound after purification by silica gel column chromatography with ethyl acetate in hexanes as eluent.

Sources & evidence

ORD record: ord-c4934542a58b4d658cae84791bac9afc
Source dataset: uspto-grants-1989_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04870187

Reaction notes

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