Lithium Hydroxide → HCID 14877951, compound

HRID 1608405Notes

Reaction equation

HRID 1608405 reaction equation
[Li+].[OH-].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)=[C:11]([N:17]2[CH:21]=[N:20][N:19]=[N:18]2)[C:12]([O:14]CC)=[O:13])=[CH:6][CH:5]=1>C(O)C.O>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:22]2[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=2)=[C:11]([N:17]2[CH:21]=[N:20][N:19]=[N:18]2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 14877950HCID 14877950, compound

Product 1

HCID 14877951HCID 14877951, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The saponification was performed by the addition of 1.14 mL of 2.0M LiOH solution to a solution of 0.27 g (0.76 mmole) of ethyl α-[bis(4-fluorophenyl)methylene]-1H-tetrazole-1-acetate in 5 mL of 95% ethanol at room temperature. After two hours, the crude reaction mixture was diluted with water and washed with diethyl ether (20 mL×2). The free acid in the aqueous layer was regenerated by the addition of aqueous HCl then extracted with diethyl ether, dried and evaporated. The crude acid was dried under high vacuum for 48 hours before it was used in the next step.

Workup

  1. customthe crude reaction mixture
  2. washwashed with diethyl ether (20 mL×2)
  3. additionThe free acid in the aqueous layer was regenerated by the addition of aqueous HCl
  4. extractionthen extracted with diethyl ether
  5. customdried
  6. customevaporated
  7. dry with materialThe crude acid was dried under high vacuum for 48 hours before it

Sources & evidence

ORD record
ord-2835b524932e4182834a0f1a4fc7a8fe
Source dataset
uspto-grants-1989_09
Patent number
US04870187

Reaction notes

Loading…