Sodium Hydroxide → HCID 20086618, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-(2,3-dichlorophenyl)-1-piperazine-acetonitrile (5.45 g, 0.0202 mol) in dry tetrahydrofuran (50 mL) is added dropwise to a suspension of lithium aluminum hydride (LiAIH4) (0.84 g, 0.210 mol) in dry tetrahydrofuran (50 mL) at 0° C. The suspension is stirred at 0° C. for 3 hours, followed by dropwise addition of 2N sodium hydroxide (NaOH). The mixture is filtered through Celite and concentrated in vacuo to give 5.7 g of the title compound as a yellow oil.

Provenance & Evidence