Sodium Hydroxide → HCID 20086618, compound

HRID 1608496Notes

Reaction equation

HRID 1608496 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]#[N:17])[CH2:11][CH2:10]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][NH2:17])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 20086616HCID 20086616, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 20086618HCID 20086618, compoundYield 102.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of 4-(2,3-dichlorophenyl)-1-piperazine-acetonitrile (5.45 g, 0.0202 mol) in dry tetrahydrofuran (50 mL) is added dropwise to a suspension of lithium aluminum hydride (LiAIH4) (0.84 g, 0.210 mol) in dry tetrahydrofuran (50 mL) at 0° C. The suspension is stirred at 0° C. for 3 hours, followed by dropwise addition of 2N sodium hydroxide (NaOH). The mixture is filtered through Celite and concentrated in vacuo to give 5.7 g of the title compound as a yellow oil.

Workup

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-eec70dde4df14a9fb4cfb1410f419dc4
Source dataset
uspto-grants-1995_03
Patent number
US05395835

Reaction notes

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