HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 22392078, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-(Trifluoromethyl)-1,3-thiazole-4-carbaldehyde | HCID 20086717 | — |
| Reactant | HCID 178418486 | HCID 178418486 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22392078 | HCID 22392078 | — |
Reaction Steps
11 ml of a molar solution of ethynyl magnesium bromide were added to a solution of tetrahydrofuran (THF) with 2 g of 2-(trifluoromethyl) 4-thiazolecarboxaldehyde and the reaction mixture was stirred for 30 minutes at about 20°-25° C. It was poured into a solution of ammonium chloride and extraction was carried out with methylene chloride. The extracts were dried, filtered and evaporated to dryness to obtain 2.1 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05395845 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-8dc4d80073444c55ac1fda4edd5bf958 |
| Source note | uspto-grants-1995_03 |