Tetrahydrofuran → HCID 22392078, compound

HRID 1608535Notes

Reaction equation

HRID 1608535 reaction equation
C([Mg]Br)#C.[O:5]1[CH2:9][CH2:8][CH2:7]C1.[F:10][C:11]([F:20])([F:19])[C:12]1[S:13][CH:14]=[C:15](C=O)[N:16]=1.[Cl-].[NH4+]>C(Cl)Cl>[C:8]([CH:9]([C:15]1[N:16]=[C:12]([C:11]([F:20])([F:19])[F:10])[S:13][CH:14]=1)[OH:5])#[CH:7]

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 25517Ammonium ChlorideHCID 200867172-(Trifluoromethyl)-1,3-thiazole-4-carbaldehydeHCID 178418486HCID 178418486, compound

Product 1

HCID 22392078HCID 22392078, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

11 ml of a molar solution of ethynyl magnesium bromide were added to a solution of tetrahydrofuran (THF) with 2 g of 2-(trifluoromethyl) 4-thiazolecarboxaldehyde and the reaction mixture was stirred for 30 minutes at about 20°-25° C. It was poured into a solution of ammonium chloride and extraction was carried out with methylene chloride. The extracts were dried, filtered and evaporated to dryness to obtain 2.1 g of the desired product.

Workup

  1. customThe extracts were dried
  2. filtrationfiltered
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-8dc4d80073444c55ac1fda4edd5bf958
Source dataset
uspto-grants-1995_03
Patent number
US05395845

Reaction notes

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