Allyl bromide → HCID 53959466, compound

HRID 1608555Notes

Reaction equation

HRID 1608555 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH3:10])[C:6](=[O:11])[NH:5][C:4](=[O:12])[C:3]=1[NH:13][C:14]([C:16]12[CH2:23][CH:22]3[CH2:24][CH:18]([CH2:19][CH:20]1[CH2:21]3)[CH2:17]2)=O.[CH2:25](Br)[CH:26]=[CH2:27]>>[CH2:27]([N:5]1[C:4](=[O:12])[C:3]2[NH:13][C:14]([C:16]34[CH2:17][CH:18]5[CH2:24][CH:22]([CH2:21][CH:20]3[CH2:19]5)[CH2:23]4)=[N:1][C:2]=2[N:7]([CH2:8][CH2:9][CH3:10])[C:6]1=[O:11])[CH:26]=[CH2:25]

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 54472978HCID 54472978, compound

Product 1

HCID 53959466HCID 53959466, compoundYield 35%

Procedure

Substantially the same procedure as in Reference Example 3 was repeated using 300 mg (0.90 mmol) of 6-amino-5-(3-tricyclo[3.3.1.03,7 ]nonylcarbonylamino)-1-propyluracil (Japanese Published Unexamined Patent Application No. 173889/91) and 0.16 ml (1.81 mmol) of allyl bromide. The obtained crude product was subjected to the same cyclization reaction that was used in Example 1, without purification, to give 110 mg (yield 35%) of Compound J as a white powder.

Workup

  1. customThe obtained crude product
  2. customwas subjected to the same cyclization reaction that
  3. customwas used in Example 1, without purification

Sources & evidence

ORD record
ord-96b3660cdc03440a9269aeb9573a594c
Source dataset
uspto-grants-1995_03
Patent number
US05395836

Reaction notes

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