HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[4-(Benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7]-decan-2-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-trityl-5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7]decan-2-amine | HCID 15198019 | — |
| Product | 5-[4-(Benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7]-decan-2-amine hydrochloride | HCID 67798427 | — |
Reaction Steps
A mixture of N-trityl-5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]decan-2-amine (200 mg) combined with ethanolic hydrogen chloride (5 ml) is stirred for an hour at room temperature. This is evaporated to dryness and the components separated via flash chromatography (eluting with 10% MeOH/CH2Cl2) to obtain 5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]-decan-2-amine hydrochloride (m.p. 278°-281° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05395846 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-65c27f7ddeaf41e6bd8cdcabfcb28a79 |
| Source note | uspto-grants-1995_03 |