5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

HRID 1608595Notes

Reaction equation

HRID 1608595 reaction equation
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[ClH:18].CO>CO>[ClH:18].[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 152293635-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridineHCID 21893726Hydrochloride methanol

Product 1

HCID 200866555-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochlorideYield 89.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

Workup

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from chloroform ether
  3. customThen, the crystals thus obtained
  4. washwere washed with ether
  5. customdried

Sources & evidence

ORD record
ord-bf831ec700804557a5bda0828d3e5c07
Source dataset
uspto-grants-1995_03
Patent number
US05395839

Reaction notes

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