反应详情

温度

80 °C

A mixture of 1-bromo-4-fluoro-3-(trifluoromethyl)benzene (5.02 g) and potassium cyanide (1.38 g) in DMSO (20 ml) was heated at 80° C. for 14 h. Water was added and the mixture was extracted ether, the organic extracts were dried (MgSO4) and evaporated to give a brown oil. This was dissolved in DMSO (10 ml) and 4 M NaOH (10 ml) and heated at 100° C. for 16 h. 2 M Hcl (20 ml) was added and the mixture was extracted with DCM (three times), the organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the sub-title compound (1.99 g).

1. extractionthe mixture was extracted ether
2. dry with materialthe organic extracts were dried (MgSO4)
3. customevaporated
4. customto give a brown oil
5. addition2 M Hcl (20 ml) was added
6. extractionthe mixture was extracted with DCM (three times)
7. dry with materialthe organic extracts were dried (MgSO4)
8. customevaporated
9. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)