3-Amino-1-propanol → HCID 20086972, compound

HRID 1608657Notes

Reaction equation

HRID 1608657 reaction equation
Cl[C:2]1[C:3](=[O:10])[N:4]([CH3:9])[N:5]=[CH:6][C:7]=1[Cl:8].[NH2:11][CH2:12][CH2:13][CH2:14][OH:15]>O>[Cl:8][C:7]1[CH:6]=[N:5][N:4]([CH3:9])[C:3](=[O:10])[C:2]=1[NH:11][CH2:12][CH2:13][CH2:14][OH:15]

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 1204623(2H)-Pyridazinone, 4,5-dichloro-2-methyl-

Product 1

HCID 20086972HCID 20086972, compoundYield 19.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.58 g (20 mmoles) of 4,5-dichloro-2-methyl-3(2H)-pyridazinone and 3.76 g (50 mmoles) of 3-aminopropanol are dissolved in 35 ml of water. The mixture is boiled for 4 hours under stirring and reflux cooling, then it is cooled and extracted with 200 ml of dichloromethane. The organic phase is dried, evaporated and the crude product is subjected to chromatography on a silica gel column. Thus 0.84 g (19%) of the desired compound is obtained. M.p.: 65°-66° C., Rf =0.7.

Workup

  1. temperaturereflux
  2. temperaturecooling
  3. temperatureit is cooled
  4. extractionextracted with 200 ml of dichloromethane
  5. customThe organic phase is dried
  6. customevaporated

Sources & evidence

ORD record
ord-bea1821563ed4c39a84d1f20c59d7c2a
Source dataset
uspto-grants-1995_03
Patent number
US05395934

Reaction notes

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