Methylamine → HCID 20086975, compound

HRID 1608660Notes

Reaction equation

HRID 1608660 reaction equation
[CH2:1]([O:8][CH2:9][N:10]1[C:15](=[O:16])[C:14]([NH:17][CH2:18][CH2:19][CH2:20]Cl)=[C:13]([Cl:22])[CH:12]=[N:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][NH2:24]>C(O)C>[CH2:1]([O:8][CH2:9][N:10]1[C:15](=[O:16])[C:14]([NH:17][CH2:18][CH2:19][CH2:20][NH:24][CH3:23])=[C:13]([Cl:22])[CH:12]=[N:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20086961HCID 20086961, compound

Product 1

HCID 20086975HCID 20086975, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.35 g (15.63 mmoles) of 2-benzyloxymethyl-5-chloro-4-[N-(3-chloropropyl)-amino]-3(2H)-pyridazinone [which can be prepared according to method 3.ii)] are dissolved in 40 ml of ethanol containing 33% of methylamine. The solution is kept at 100° C. for 5 hours in a pressure-tight steel tube. The solvent is evaporated and the residue is subjected to chromatography on a silica gel column. Thus 4.19 g (80%) of the desired compound are obtained. Rf =0.35.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-08facef0917341d8b51e6d3c3806bd7f
Source dataset
uspto-grants-1995_03
Patent number
US05395934

Reaction notes

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