Ethanol → (Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine

HRID 1608683Notes

Reaction equation

HRID 1608683 reaction equation
[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6]C[CH2:4]2.C([OH:13])C>[Pd]>[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6][O:13][CH2:4]2

Participants

4

Reactant 2

HCID 702EthanolHCID 22924372HCID 22924372, compound

Product 1

HCID 19960957(Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2.8 g (12.1 mmol) of 1-aminomethyl-7-azabicyclo[3.3.0]octane are dissolved in 50 ml of ethanol and hydrogenated on 0.3 g of palladium-active charcoal at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationdistilled

Sources & evidence

ORD record
ord-0e0aef67e0394252bb0e6735a627bdb6
Source dataset
uspto-grants-1995_03
Patent number
US05395944

Reaction notes

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