Hydrochloric Acid → HCID 67726691, compound

HRID 1608685Notes

Reaction equation

C(OC([NH:8][CH2:9][C:10]12[CH2:17][N:16]([C:18]3[C:27]([F:28])=[C:26]4[C:21]([C:22](=[O:35])[C:23]([C:32]([OH:34])=[O:33])=[CH:24][N:25]4[CH:29]4[CH2:31][CH2:30]4)=[C:20]([F:36])[C:19]=3[F:37])[CH2:15][CH:14]1[CH2:13][CH2:12][O:11]2)=O)(C)(C)C.[ClH:38]>>[ClH:38].[NH2:8][CH2:9][C:10]12[CH2:17][N:16]([C:18]3[C:27]([F:28])=[C:26]4[C:21]([C:22](=[O:35])[C:23]([C:32]([OH:34])=[O:33])=[CH:24][N:25]4[CH:29]4[CH2:31][CH2:30]4)=[C:20]([F:36])[C:19]=3[F:37])[CH2:15][CH:14]1[CH2:13][CH2:12][O:11]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 199609587-(1-Tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Product 1

HCID 67726691HCID 67726691, compound

Procedure

In an analogous manner to Example 1B, the product from step A is reacted with half-concentrated hydrochloric acid to give 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride with a melting point of 175°-177° C. (with decomposition).

Sources & evidence

ORD record: ord-6a06acce719b4aefb004549134dafd38
Source dataset: uspto-grants-1995_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05395944

Reaction notes

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