Potassium Acetate → HCID 88305560, compound

HRID 1608778Notes

Reaction equation

HRID 1608778 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3](/[CH:10]=[C:11]2\[C:12](=[O:20])[NH:13][C:14]3[C:19]\2=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:2]1.[C:21]([O-])(=[O:23])[CH3:22].[K+]>C(OC(=O)C)(=O)C>[C:21]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3](/[CH:10]=[C:11]2\[C:12](=[O:20])[NH:13][C:14]3[C:19]\2=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:2]1)(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 10199113HCID 10199113, compound

Product 1

HCID 88305560HCID 88305560, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of (Z)-3-[(7-azaindol-3-yl)methylen]-2-oxindole (2.61 g, 0.010 mol), potassium acetate (0.98 g, 0.010 mol) and acetic anhydride (10 ml) is heated at reflux temperature for 15 h and then concentrated under vacuum. The residue is taken up with ethyl acetate and water, the organic phase separated, washed with water, dried over Na2SO4 and evaporated under vacuum. The residue is crystallized from ethanol to give pure title compound in 65% yield.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature for 15 h
  3. concentrationconcentrated under vacuum
  4. customthe organic phase separated
  5. washwashed with water
  6. dry with materialdried over Na2SO4
  7. customevaporated under vacuum
  8. customThe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-03afa358dc984a66a4c25337793a13f9
Source dataset
uspto-grants-1995_03
Patent number
US05397787

Reaction notes

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