反应详情

5.6 g of 2-amino-2',5-dichlorobenzophenone and 5 g of 3,4-dimethoxyphenylsulfonyl chloride are heated in pyridine at 100° C. overnight. The pyridine is evaporated to dryness, water is added and extraction is carried out with ethyl acetate containing a small amount of DCM. After washing more than once with water and drying over sodium sulfate, the extract is evaporated under vacuum and 7.7 g of the expected product are recrystallized in a DCM/AcOEt mixture.

1. customThe pyridine is evaporated to dryness, water
2. additionis added
3. extractionextraction
4. washAfter washing more than once with water
5. dry with materialdrying over sodium sulfate
6. customthe extract is evaporated under vacuum and 7.7 g of the expected product
7. customare recrystallized in a DCM/AcOEt mixture