Potassium Carbonate → HCID 54275513, compound

HRID 1608953Notes

Reaction equation

HRID 1608953 reaction equation
C([O:3][C:4](=[O:24])[CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)C.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH:17]=[CH:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[O:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:24])=[O:3]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 54020649HCID 54020649, compound

Product 1

HCID 54275513HCID 54275513, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 32.5 g (0.1 mol) of compound of Example 6, 450 ml 50 percent ethanol and 27 g potassium carbonate is heated under reflux for 2 h, evaporated, the residue taken up in water, washed with ether, the aqueous phase adjusted to pH 6.5 and the precipitate filtered off. After trituration with ether, one isolates 12.1 g of title compound (41% of theory) of the m.p. 90°-93° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 2 h
  3. customevaporated
  4. washwashed with ether
  5. filtrationthe precipitate filtered off

Sources & evidence

ORD record
ord-bfb42a9b3ac343049073198dc8faee2c
Source dataset
uspto-grants-1995_03
Patent number
US05399575

Reaction notes

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