Water → HCID 54344046, compound

HRID 1608956Notes

Reaction equation

HRID 1608956 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1)=O.[CH3:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1.C(OC(=O)C)(=O)C.O>ClCCl>[N:23]1[CH:24]=[CH:25][C:20]([CH:19]=[CH:1][C:3]2[CH:8]=[CH:7][C:6]([CH2:9][O:10][C:11]3[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=3)=[CH:5][CH:4]=2)=[CH:21][CH:22]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 79634-MethylpyridineHCID 20083430HCID 20083430, compound

Product 1

HCID 54344046HCID 54344046, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 9.8 g (40 mmol) 4-(4-formylphenylmethoxy)-benzonitrile, 4 ml (40 mmol) 4-methylpyridine and 4 ml acetic acid anhydride is heated to 120° C. for 18 h. One mixes with water, extracts with dichloromethane, dries the extract, evaporates and triturates with ether. One isolates 6.1 g of title compound (49% of theory) of the m.p. 149°-150° C.

Workup

  1. customevaporates

Sources & evidence

ORD record
ord-c7594c88b94d44adad69165e84c51793
Source dataset
uspto-grants-1995_03
Patent number
US05399575

Reaction notes

Loading…