Hydrochloric Acid → HCID 67810354, compound

HRID 1609013Notes

Reaction equation

HRID 1609013 reaction equation
[ClH:1].[C:2]([C:5]1[CH:28]=[CH:27][C:8]([C:9]([NH:11][CH2:12][C:13]([C:15]2[CH:26]=[CH:25][C:18]([CH2:19][CH2:20][C:21]([O:23]C)=[O:22])=[CH:17][CH:16]=2)=[O:14])=[O:10])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].Cl>O>[ClH:1].[C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:11][CH2:12][C:13]([C:15]2[CH:16]=[CH:17][C:18]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)=[O:14])=[O:10])=[CH:27][CH:28]=1)(=[NH:3])[NH2:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20083716HCID 20083716, compound

Product 1

HCID 67810354HCID 67810354, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
5 °C

Procedure

100 mg of methyl p-(p-amidinobenzamidoacetyl)hydrocinnamate hydrochloride were heated with 4 ml of 2 N hydrochloric acid at 100° C. for 60 minutes. The reaction mixture was cooled, 4 ml of water were added, and the mixture was stirred at 5° C. for 2 hours. The crystals which precipitated was filtered off with suction and dried over KOH in vacuo. 70 mg of pure p-(p-amidinobenzamidoacetyl)hydrocinnamic acid hydrochloride, melting point 273°-274° C. (decomposition), were obtained.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customThe crystals which precipitated
  3. filtrationwas filtered off with suction
  4. dry with materialdried over KOH in vacuo

Sources & evidence

ORD record
ord-6cc207d9cb6e47a58d379ceb672f1b3b
Source dataset
uspto-grants-1995_03
Patent number
US05399585

Reaction notes

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