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HRID1609020

反应详情

EQUATION

反应方程式

HRID 1609020 的结构方程式

REACTANTS

反应物

3
结构：CC(C)=O.CI
HCID18326933

未命名化合物

结构：S.c1ccncc1
HCID18424405

未命名化合物

结构：CC(C)(C)OC(=O)COc1ccc(C[C@H](CO)NC(=O)c2ccc(C#N)cc2)cc1
HCID53905723

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)COc1ccc(C[C@H](CO)NC(=O)c2ccc(C(=N)N)cc2)cc1
HCID53835936

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.O
溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

3.14 g of t-butyl p-[(R)-2-(p-cyanobenzamido)-3-hydroxypropyl]phenoxyacetate were successively reacted with H2S/pyridine, CH3I/acetone and NH4OAc/methanol as described in Example 1. After chromatography on silica gel with water/methanol (100:0 1:1), 1.2 g of t-butyl p-[(R)-2-(p-amidinobenzamido)-3-hydroxypropyl]phenoxyacetate were obtained in the form of a white foam. MS: 428 (M+1).