Hydrochloric Acid → HCID 86747319, compound

HRID 1609056Notes

Reaction equation

HRID 1609056 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][C@H:13]1[C@@H:17]([CH3:18])[CH2:16][N:15]([C:19]2[C:28]([F:29])=[CH:27][C:26]3[C:30](=[O:36])[C:31]([C:33]([OH:35])=[O:34])=[CH:32][N:24]4[C:25]=3[C:20]=2[CH2:21][CH2:22][N:23]4[CH3:37])[CH2:14]1)=[O:11])=O)(C)(C)C.C(O)C.[ClH:41]>O1CCOCC1>[ClH:41].[NH2:8][CH2:9][C:10]([NH:12][C@H:13]1[C@@H:17]([CH3:18])[CH2:16][N:15]([C:19]2[C:28]([F:29])=[CH:27][C:26]3[C:30](=[O:36])[C:31]([C:33]([OH:35])=[O:34])=[CH:32][N:24]4[C:25]=3[C:20]=2[CH2:21][CH2:22][N:23]4[CH3:37])[CH2:14]1)=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 86747318HCID 86747318, compound

Product 1

HCID 86747319HCID 86747319, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

750 mg (1.5 mmol) of the compound (84) obtained in Example 10 (1) was added to 10 ml of dioxane and 10 ml of ethanol, and then 2.5 ml of 4N hydrochloric acid solution in dioxane was added to the solution. The solution was stirred at room temperature for 1 hour, and the solvent was removed by distillation. The powder was filtered off and washed successively with ethanol and ether to obtain 324 mg of the subject compound (88) in a 49% yield. The result of the analysis of this compound was as follows.

Workup

  1. customthe solvent was removed by distillation
  2. filtrationThe powder was filtered off
  3. washwashed successively with ethanol and ether

Sources & evidence

ORD record
ord-c5ae41adf3a7466eb99f6daaf5880e37
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

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