Hydrochloric Acid → HCID 178469602, compound

HRID 1609066Notes

Reaction equation

HRID 1609066 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:13][CH2:14][O:15][Si](C(C)(C)C)(C)C)[C:11]=1[F:12])[N:8]=[CH:7][C:6]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:5]2[OH:28].C(Cl)(Cl)Cl.CO.Cl>O1CCOCC1.C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:13][CH2:14][OH:15])[C:11]=1[F:12])[N:8]=[CH:7][C:6]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:5]2[OH:28]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6212ChloroformHCID 178469605HCID 178469605, compound

Product 1

HCID 178469602HCID 178469602, compoundYield 90.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

5.62 g (13 mmol) of the compound (129) obtained above was added in a mixture solvent of 100 ml of chloroform and 100 ml of methanol, and 15 ml of 4N hydrochloric acid solution in dioxane was added to the solution. After stirring at room temperature for 30 minutes, the solvent was removed from the solution by distillation. Crystals obtained were dispersed in ethanol and filtrated. They were washed with ethanol and ether in this order to obtain 3.70 g of the subject compound (130) in a 90% yield.

Workup

  1. additionwas added to the solution
  2. customthe solvent was removed from the solution by distillation
  3. customCrystals obtained
  4. filtrationfiltrated
  5. washThey were washed with ethanol and ether in this order

Sources & evidence

ORD record
ord-46135c88f0cc47c8b38ee19a4be132a1
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

Loading…