Hydrochloric Acid → HCID 54253840, compound

HRID 1609080Notes

Reaction equation

HRID 1609080 reaction equation
[F:1][C:2]1[C:3]([CH:22](C#N)[C:23]([O:25]CC)=[O:24])=[C:4]2[C:9]3=[C:10]([C:12](=[O:20])[C:13]([C:15]([O:17]CC)=[O:16])=[CH:14][N:8]3[N:7]([CH3:21])[CH2:6][CH2:5]2)[CH:11]=1.Cl>C(O)(=O)C>[C:15]([C:13]1[C:12](=[O:20])[C:10]2[C:9]3[N:8]([CH:14]=1)[N:7]([CH3:21])[CH2:6][CH2:5][C:4]=3[C:3]([CH2:22][C:23]([OH:25])=[O:24])=[C:2]([F:1])[CH:11]=2)([OH:17])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20083164HCID 20083164, compound

Product 1

HCID 54253840HCID 54253840, compoundYield 34.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 450 mg of the compound (161) obtained in Example 39, 4 ml of concentrated hydrochloric acid and 16 ml of acetic acid were added, and the solution was heated at reflux for 7.5 hours. The solvent was removed by distillation, and crystals were filtered off and washed with ethanol and ether in this order to obtain 124 mg of the subject compound (163).

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 7.5 hours
  3. customThe solvent was removed by distillation, and crystals
  4. filtrationwere filtered off
  5. washwashed with ethanol and ether in this order

Sources & evidence

ORD record
ord-4922f59e63054e14a483c2b8e2d6c8ba
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

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