Triethylamine → HCID 20083141, compound

HRID 1609081Notes

Reaction equation

HRID 1609081 reaction equation
[C:1]([C:4]1[C:5](=[O:23])[C:6]2[C:15]3[N:14]([CH:16]=1)[N:13]([CH3:17])[CH2:12][CH2:11][C:10]=3[C:9]([CH2:18]C(O)=O)=[C:8]([F:22])[CH:7]=2)([OH:3])=[O:2].C(N(CC)CC)C>C(O)C>[F:22][C:8]1[C:9]([CH3:18])=[C:10]2[C:15]3=[C:6]([C:5](=[O:23])[C:4]([C:1]([OH:3])=[O:2])=[CH:16][N:14]3[N:13]([CH3:17])[CH2:12][CH2:11]2)[CH:7]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 54253840HCID 54253840, compound

Product 1

HCID 20083141HCID 20083141, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 mg of the compound (163) obtained in Example 40 and 1.4 ml of triethylamine were added to 5 ml of ethanol, and the solution was heated at reflux for 15.5 hours. After air-cooling, the solids were filtered and washed successively with ethanol and ether to obtain 65 mg of the subject compound (164).

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 15.5 hours
  3. temperatureAfter air-cooling
  4. filtrationthe solids were filtered
  5. washwashed successively with ethanol and ether

Sources & evidence

ORD record
ord-188d54b4d8d84cd7b1c8e5cd4a490dfa
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

Loading…