Methanol → HCID 20083159, compound

HRID 1609091Notes

Reaction equation

HRID 1609091 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][OH:23].[CH2:24](N(S(F)(F)F)CC)C.CO>O1CCCC1>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][O:23][CH3:24]

Participants

5

Reactant 3

HCID 887MethanolHCID 123472(Diethylamino)sulfur trifluorideHCID 20083158HCID 20083158, compound

Product 1

HCID 20083159HCID 20083159, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

65 mg of the compound (177) obtained in Example 54 was suspended in 5 ml of tetrahydrofuran, and 270 μl of diethylaminosulfurtrifluoride was added to the solution. The solution was stirred for 4 hours, and 1 ml of methanol was added to the solution. The deposited solid matter was filtered off and washed with ether to obtain 34 mg of the subject compound (180).

Workup

  1. filtrationThe deposited solid matter was filtered off
  2. washwashed with ether

Sources & evidence

ORD record
ord-a96da366039c4cd5861c82e820af5bf9
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

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