Ethanol → HCID 67796798, compound

HRID 1609092Notes

Reaction equation

HRID 1609092 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14](C(OCC)=O)=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][OH:23].C(N(S(F)(F)F)[CH2:27][CH3:28])C.[CH2:33]([OH:35])[CH3:34].[O:36]1CCC[CH2:37]1>>[F:1][CH:2]1[C:11]([F:12])([C:37]([O:35][CH2:33][CH3:34])=[O:36])[CH:10]=[C:9]2[C:13](=[O:21])[CH:14]=[CH:15][N:7]3[C:8]2=[C:3]1[CH2:4][CH2:5][N:6]3[CH2:22][O:23][CH2:27][CH3:28]

Participants

5

Reactant 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 123472(Diethylamino)sulfur trifluorideHCID 20083158HCID 20083158, compound

Product 1

HCID 67796798HCID 67796798, compound

Procedure

65 mg of the compound (177) obtained in Example 54 was suspended in 5 ml of tetrahydrofuran, and 270 μl of diethylaminosulfurtrifluoride was added to the solution. The solution was stirred for 4 hours, and 1 ml of ethanol was added to the solution. The deposited solid matter was filtered off and washed with ether to obtain 28 mg of the subject compound (181).

Workup

  1. filtrationThe deposited solid matter was filtered off
  2. washwashed with ether

Sources & evidence

ORD record
ord-f4ca35e2efc8467096f549d036621f4a
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

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