Acetic Acid → HCID 20083176, compound

HRID 1609096Notes

Reaction equation

HRID 1609096 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[C:12](=[O:19])[C:13]([C:15]([O:17]C)=[O:16])=[CH:14][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:20].Cl.C(O)(=O)C>O>[F:1][C:2]1[CH:11]=[CH:10][C:9]2[C:12](=[O:19])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:20]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 20083129HCID 20083129, compound

Product 1

HCID 20083176HCID 20083176, compoundYield 81.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 40 mg (0.14 mmol) of the compound (190) obtained in Example 63, 0.3 ml of concentrated hydrochloric acid and 1.2 ml of acetic acid were added, and the solution was heated at reflux for 3 hours. After air-cooling, 5 ml of water was added to the solution, and deposited crystals were filtered off and washed with water, ethanol and ether in this order to obtain 30 mg of the subject compound (191) in a 79% yield.

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 3 hours
  3. temperatureAfter air-cooling
  4. filtrationwere filtered off
  5. washwashed with water, ethanol and ether in this order

Sources & evidence

ORD record
ord-e64c9782cd694142b95966797528e68e
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

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