Acetic Acid → HCID 20083130, compound

HRID 1609104Notes

Reaction equation

HRID 1609104 reaction equation
[F:1][C:2]1[C:11]([F:12])=[C:10]([NH2:13])[C:9]2[C:14](=[O:22])[C:15]([C:17]([O:19]CC)=[O:18])=[CH:16][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH3:23].C(O)(=O)C.Cl>O>[NH2:13][C:10]1[C:9]2[C:14](=[O:22])[C:15]([C:17]([OH:19])=[O:18])=[CH:16][N:7]3[C:8]=2[C:3]([CH2:4][CH2:5][N:6]3[CH3:23])=[C:2]([F:1])[C:11]=1[F:12]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 21733326HCID 21733326, compound

Product 1

HCID 20083130HCID 20083130, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

20 mg of the compound (201) obtained in Example 72 was added to 0.4 ml of acetic acid and 0.1 ml of 12N hydrochloric acid, and the solution was heated at 100° C. for 2 hours. After air-cooling, the water was added to the reaction solution, and the deposited solids were filtered off and washed consecutively with water, ethanol and ether to obtain 13 mg of the subject compound (202) in a 72% yield.

Workup

  1. temperatureAfter air-cooling
  2. filtrationthe deposited solids were filtered off
  3. washwashed consecutively with water, ethanol and ether

Sources & evidence

ORD record
ord-922bfada70a74502b50e61d4bd1a55e4
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

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