Dimethyl Sulfate → 5-Bromo-6-methoxy-2-naphthaldehyde

Participants

Reaction Steps

Step c) A mixture of 5-bromo-6-hydroxy-2-naphthaldehyde (34.0 g, 135.5 mmol), potassium carbonate (18.7 g, 135.5 mmol), dimethyl sulfate (12.8 mL, 135.5 mmol) and acetone (500 mL), was refluxed for 3 hours. The volatiles were removed in vacuo, and the residue was suspended in water. The precipitated solid was filtered and dried, to yield a yellow solid (34.5 g, 96 % yield, m.p. 133°-135° C.).

Provenance & Evidence