Dimethyl Sulfate → 5-Bromo-6-methoxy-2-naphthaldehyde

HRID 1609126노트

반응식

HRID 1609126 반응식
[Br:1][C:2]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH:13]=[O:14])=[CH:7]2.[C:15](=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>CC(C)=O>[Br:1][C:2]1[C:11]([O:12][CH3:15])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH:13]=[O:14])=[CH:7]2

참가 물질

5

반응물 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 189963195-Bromo-6-hydroxy-2-naphthaldehyde

생성물 1

HCID 185053535-Bromo-6-methoxy-2-naphthaldehyde수율 96%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Step c) A mixture of 5-bromo-6-hydroxy-2-naphthaldehyde (34.0 g, 135.5 mmol), potassium carbonate (18.7 g, 135.5 mmol), dimethyl sulfate (12.8 mL, 135.5 mmol) and acetone (500 mL), was refluxed for 3 hours. The volatiles were removed in vacuo, and the residue was suspended in water. The precipitated solid was filtered and dried, to yield a yellow solid (34.5 g, 96 % yield, m.p. 133°-135° C.).

후처리

  1. temperaturewas refluxed for 3 hours
  2. customThe volatiles were removed in vacuo
  3. filtrationThe precipitated solid was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-0f2becf1ad7d4aafa4f3ebf06e5269d7
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399588

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