反应详情

Step d) Sodium borohydride (4.78 g, 128.3 mmol) was added portionwise in to a cold (0° C.) mixture of 5-bromo-6-methoxy-2-naphthldehyde (34.0 g, 128.3 mmol) in methanol (300 ml) and THF (200 mL). After stirring for 30 minutes the mixture was poured in to water and extracted with EtOAc. The organic extracts were dried over MgSO4. Evaporation and purification by flash chromatography (hexane/EtOAc 2/1) gave a yellow solid (30.5 g, 90% yield, m.p. 85°-87° C.).

1. extractionextracted with EtOAc
2. dry with materialThe organic extracts were dried over MgSO4
3. customEvaporation and purification by flash chromatography (hexane/EtOAc 2/1)